TCR-T and CAR-T/NK/MA Cell Immunometabolism

Immune cells use well-known oxidative phosphorylation, glycolysis pathways, and fatty acid oxidation to achieve different immune functions. In most cases, immune cells use and respond to nutrients like other cells. Many factors influence the metabolic state of any particular cell. These include cell-specific factors such as cell type and cell status (activation, differentiation, proliferation, migration). Taking T cells as an example, the serine/threonine kinase AKT, AMPK (AMP-activated protein kinase), mTOR (mammalian target of rapamycin) and LKB1 are generally considered to be cell nutrition sensors, which determine how cells respond by transmitting high or equal signals to help maintain energy homeostasis. AKT, AMPK and LKB1 control the fate transition from cytotoxic effectors to memory CD8+ T cells.

At Creative Biolabs, we offer a variety of accurate and direct cellular metabolic analyses, see the list below. The assay can be performed in a 96-well plate and the results can be analyzed by fluorometry and/or colorimetry.

Overview of T Cell Metabolism in Tumor Environment

Fig 1 T Cell Metabolism (Kouidhi S,2017

For more details, please feel free to contact us for project quotations and more detailed information.

Reference

1. 1. Kouidhi S.; et al. Impact of Metabolism on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment. Frontiers in Immunology, 2017, 8(1).

For Research Use Only | Not For Clinical Use